Metabolism
R26-pAPOE-hCYP3A4(FVB)
R26-pAPOE-hCYP3A4(FVB)
Nomenclature
FVB-Gt(ROSA)26Sortm1(pAPOE-CYP3A4)/IL
Cat. NO.ILKI-18032
Strain StateEmbryo
Gene Summary:
| Synonyms | R26, ROSA26, AV258896, Gtrgeo26, Gtrosa26, Thumpd3as1 |
| NCBI ID | 14910 |
| MGI ID | 104735 |
| Ensembl ID | ENSMUSG00000086429 |
| Human Orthologs | CYP3A4 |
Research Application:
Description:
This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with ILKI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.