Leptin resistance, insulin resistance, obesity, and type 2 diabetes etc.
Lepr-g.G109052T
Lepr-g.G109052T
Nomenclature
B6.129S-Leprtm1/IL
Cat. NO.ILKI-00001
Strain StateEmbryo
Gene Summary:
| Synonyms | db, Obr, obl, Leprb, Modb1, LEPROT, OB-RGRP, diabetes, obese-like |
| NCBI ID | 16847 |
| MGI ID | 104993 |
| Ensembl ID | ENSMUSG00000057722 |
| Human Orthologs | LEPR |
Research Application:
Description:
A point mutation was introduced to exon 19 (c.109052 G>T) via a recombineering strategy. Homozygous mutants are hyperphagic, low-activity, poorly cold-adapted, sterile and have enhanced fat conversion.