Immunotherapy, drug screening
IL11 & IL11RA
IL11 & IL11RA
Nomenclature
C57BL/6-Il11em1(hIL11)Il11ra1tm1(hIL11RA)/IL
Cat. NO.ILHU-210372
Strain StateLive
Gene Summary:
| Synonyms | IL-11, NR1, GP130, Il11ra, Il-11ra, Il11ra2, AI314697 |
| NCBI ID | 16156, 16157 |
| MGI ID | 107613, 107426 |
| Ensembl ID | ENSMUSG00000004371, ENSMUSG00000073889 |
| Human Orthologs | IL11, IL11RA1 |
Research Application:
Description:
hIL11(ILHU-204981) was crossed with hIL11RA (ILHU-204982) to generate hIL11/hIL11RA mice.
Validation Data
Figure 1. Detection of IL11 and IL11RA expression in testis, stomach and lung by RT-PCR. Wild type: only one band at 171 bp with primers F1/R1 (mIl11), Homozygous: only one band at 162 bp with primers F2/R2 (hIL11). Abbr. M, DNA marker, HO, homozygous, WT, wild type.
Figure 2. Detection of hIL11 expression in lung homogenate by ELISA. Abbr. HO, homozygous, WT, wild type. Note. hIL11/hIL11RA and C57BL/6 mice were injected with LPS.
Figure 3. Detection of hIL11RA expression in Kidney in C57BL/6 and HO/HO hIL11/hIL11RA knock-in mice by IHC. Abbr. HO/HO, homozygous, WT, wild type. Note. The anti-human IL11RA Antibody cross-reacted with mouse IL11RA and humanized IL11RA.