The endogenous mice Cd2 gene was replaced by human CD2 gene.
Validation Data
Figure1. Detection of CD2 expression in thymus and spleen by RT-PCR. Wild type: only one band at 432 bp with primers F1/R1 (mCd2), Heterozygous: one band at 432 bp with primers F1/R1 (mCd2) and one band at 228 bp with primers F2/R2 (hCD2), Abbr. M, DNA marker, HO, homozygous, HE, heterozygous, WT, wild type.
Figure 2. Detection of hCD2 expression on Jurkat cell line.
Figure 3. Detection of hCD2 expression on T cells in Blood in hCD2 KI mice.
Figure 4. Detection of hCD2 expression on T cells in Spleen in hCD2 KI mice.
Figure 5. Detection of hCD2 expression on B cells in hCD2 KI mice.
Figure 6. Detection of hCD2 expression on NK cells in hCD2 KI mice.