CD40 & 4-1BB (2)

Nomenclature
C57BL/6-Cd40em1(hCD40)Tnfrsf9tm2(TNFRSF9)/IL
Cat. NO.ILHU-200256
Strain StateEmbryo

Gene Summary:

SynonymsIGM, p50, Bp50, GP39, IMD3, TRAP, HIGM1, T-BAM, Tnfrsf5, AI326936, ILA, Ly63, 4-1BB, Cd137, CDw137, AA408498, AI325004, A930040I11Rik
NCBI ID21939, 21942
MGI ID88336, 1101059
Ensembl IDENSMUSG00000017652, ENSMUSG00000028965
Human OrthologsCD40, TNFRSF9

Research Application:

Immunotherapy, drug screening

Description:

Validation Data

landingpage-ashu-200256-cd40&amp,4-1bb-hu-icpmouse-2

Figure1. In vivo validation of double humanized CD40&amp,4-1BB mice. Double humanized mice were inoculated with B16F10 cells, and randomly assigned to different groups (n=6) when the tumor grew to a volume of 80 mm3. A combinatorial treatment of anti-CD40 and anti-4-1BB inhibited tumor growth (top) without affecting the animal body weight (Bottom).