Cytokine humanization model, drug screening
IL2RB
IL2RB
Nomenclature
C57BL/6-Il2rbtm1(hIL2RB)/IL
Cat. NO.ILHU-2000055
Strain StateEmbryo
Gene Summary:
| Synonyms | p70, CD122, IL15Rbeta, Il-2Rbeta, IL-15Rbeta, Il-2/15Rbeta |
| NCBI ID | 16185 |
| MGI ID | 96550 |
| Ensembl ID | ENSMUSG00000068227 |
| Human Orthologs | IL2RB |
Research Application:
Description:
The endogenous mouse Il2rb gene was replaced by human IL2RB gene.
Validation Data
Figure 1. Analysis of IL2RB gene expression in the liver by RT-PCR.
Mouse Il2rb mRNA was detectable by P1/2 (511bp), human IL2RB mRNA was detectable by P1/3(513bp)
M:100bp Plus DNA ladder from Transgen (BM311). The heterozygous KI mouse expresses both human IL2RB and mouse Il2rb in the liver.