Immunotherapy, cancer research, drug screening
CSF1R (2)
CSF1R (2)
Nomenclature
C57BL/6-Csf1rem2(hCSF1R)/IL
Cat. NO.ILHU-190074
Strain StateEmbryo
Gene Summary:
| Synonyms | Fms, Fim2, CD115, Csfmr, Fim-2, CSF-1R, M-CSFR, M-CSF-R, AI323359 |
| NCBI ID | 12978 |
| MGI ID | 1339758 |
| Ensembl ID | ENSMUSG00000024621 |
| Human Orthologs | CSF1R |
Research Application:
Description:
Validation Data
Figure 1. Detection of CSF1R(2) expression in spleen by RT-PCR.
Wild type: only one band at 233 bp with primers F1/R1(mCsf1r(2)), Homozygous: only one band at 345 bp with primers F2/R2(hCSF1R(2)), Abbr.. M, DNA marker, HO, homozygous, HE, heterozygous, WT, wild type.
Figure 2. FPA008 and human CSF-1R test Ab can effectively inhibit the growth of bone marrow cells in huCSF-1R mice, confirming that this model is an appropriate platform for human anti-CSF-1R antibody evaluation.（FPA008, BMS, phase II）
Figure 3. Dose-dependent effect of huCSF-1R inhibitors on block the proliferation of macrophages in huCSF-1R mice.