APOE4

Nomenclature
C57BL/6 - Apoetm2(hAPOE4)/IL
Cat. NO.ILHU-190002
Strain StateLive

Gene Summary:

SynonymsApo-E, AI255918
NCBI ID11816
MGI ID88057
Ensembl IDENSMUSG00000002985
Human OrthologsAPOE

Research Application:

Cardiovascular disease

Description:

Humanized Strategy

APOE4 Humanized Immune Checkpoint Mouse Model

Validation Data

APOE4 Humanized Immune Checkpoint Mouse Model

Figure 1. Genotyping of WT, KO &amp,&nbsp, Humanized mice by PCR. Primer P1/2 Wild type = 342 bp Primer P3/4 mutant = 332 bp M：100bp Plus DNA ladder.

APOE4 Humanized Immune Checkpoint Mouse Model

Figure 2. Western blot analysis of&nbsp, APOE4 protein from WT, KO &amp, Humanized mice.&nbsp, APOE anti-body: Sc-13521 (santa cruz)

Validate Human APOE Expression by Western Blot

APOE4 Humanized Immune Checkpoint Mouse Model

KO: Apoe knockout mouse sample, hAPOE2 : humanized APOE2 mouse sample (ASHU-190013), hAPOE3 : humanized APOE3 mouse sample (ASHU-190003), hAPOE4 : humanized APOE4 mouse sample (ASHU-190002), WT: wild type mouse sample, M: marker.