Immunotherapy, cancer research, drug screening
ICOS & ICOSL
ICOS & ICOSL
Nomenclature
C57BL/6-Icoslem1(hICOSLG) Icosem1(hICOS)/IL
Cat. NO.ILHU-18018
Strain StateLive
Gene Summary:
| Synonyms | AILIM, CCLP, CRP-1, H4, Ly115, B7h, GI50, GL50, B7-H2, LICOS, B7RP-1, GL50-B, ICOS-L, Icoslg, Ly115l, AU044799, BG071784, Mkiaa0653 |
| NCBI ID | 54167, 50723 |
| MGI ID | 1858745, 1354701 |
| Ensembl ID | ENSMUSG00000026009, ENSMUSG00000000732 |
| Human Orthologs | ICOS, ICOSLG |
Research Application:
Description:
This ICOS and ICOSL double knock-in strain is established by crossing ICOS-HU and ICOSL-HU mice. These double double knock-in mice can be useful for evaluating the efficacy of potential immunotherapy drug combinations.
Validation Data
Figure 1. Detection of hICOS expression on MOLT-4 cell line.
Figure 2. Detection of hICOS expression on activated T cells by anti-mCD3 in hICOS/hICOSL dKI mice.