Immunotherapy, cancer research, drug screening
PD-L1 & LAG3
PD-L1 & LAG3
Nomenclature
C57BL/6 - Cd274em1(hPD - L1)Lag3tm1(hLAG3)/IL
Cat. NO.ILHU-00137
Strain StateEmbryo
Gene Summary:
| Synonyms | B7h1, Pdl1, Pdcd1l1, Pdcd1lg1, A530045L16Rik, Ly66, CD223, LAG-3 |
| NCBI ID | 60533, 16768 |
| MGI ID | 1926446, 106588 |
| Ensembl ID | ENSMUSG00000016496, ENSMUSG00000030124 |
| Human Orthologs | CD274, LAG3 |
Research Application:
Description:
Humanized Strategy
Strategy for Generating Humanized PD-L1 (ASHU-00062) Mouse Model
Strategy for Generating Humanized LAG3 (ASHU-00049) Mouse Model
Validation Data
Figure 1. Splenocytes from homozygous hPDL1/hLAG3 mice were analyzed by flow cytometry after activation. The mPDL1+ and mLAG3+ cells were detectable in wild type (WT) C57BL/6 mice, while the hPDL1+ and hLAG3+ cells were detectable in the homozygous hPD1/hLAG3 mice.