Immunotherapy, DTR mouse
Lyz2-IRES-DTREGFP
Lyz2-IRES-DTREGFP
Nomenclature
C57BL/6-Lyz2em3(IRES-DTREGFP)/Asc
Cat. NO.ASKI-190041
Strain State
Gene Summary:
| Synonyms | Lys, Lysm, Lyzs, Lzm, Lzm-s1, Lzp |
| NCBI ID | 17105 |
| MGI ID | 96897 |
| Ensembl ID | ENSMUSG00000069516 |
| Human Orthologs | LYZ |
Research Application:
Description:
Validation Data
Figure 1: Analysis of GFP expression by FACS. The Lyz2-DTRGFP mouse expresses GFP on CD11b+ cells.
Figure 2: Analysis of the level of different immune cells in PBMC by FACS (See Figure 4 for details of diphtheria toxin injection).
Figure 3: Analysis of the level of different immune cells in the spleen and transplanted tumor by FACS (See Figure 4 for details of diphtheria toxin injection).
Figure 4: The growth of MC38 tumors in Lyz2-DTRGFP mice and C57BL/6 mice. Heterozygous Lyz2-DTRGFP mice and C57BL/6 mice were inoculated with MC38 colon cancer cells. The Lyz2-DTRGFP mice were injected with diphtheria toxin twice a week. (Data in partnership with collaborators.)
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