Immunotherapy
R26-(CAG-LSL-EML4-ALK(F1174L)-luciferase-tdTomato)
R26-(CAG-LSL-EML4-ALK(F1174L)-luciferase-tdTomato)
Nomenclature
C57BL/6J-Gt(ROSA)26Sorem1(SA-2xpolyA-CAG-LSL-EML4-ALK(F1174L)-IRES-luciferase-2A-tdTomato)Asc
Cat. NO.ASKI-190010
Strain State
Gene Summary:
| Synonyms | |
| NCBI ID | 14910 |
| MGI ID | 104735 |
| Ensembl ID | ENSMUSG00000086429 |
| Human Orthologs |
Research Application:
Description:
A SA-2xpolyA-CAG-LSL-EML4-ALK(F1174L)-IRES-Luciferase-2A-tdTomato-WPRE-polyA cassette was inserted at the Rosa26 locus using CRISPR gene editing technology. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the EML4-ALK(F1174L) protein.