Immunotherapy
R26-(Gut-CYP3A4)
R26-(Gut-CYP3A4)
Nomenclature
FVB-Gt(ROSA)26Sorem1(Gut-CYP3A4-IRES-tdTomato)Asc
Cat. NO.ASKI-18033
Strain State
Gene Summary:
| Synonyms | HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1 |
| NCBI ID | 1576 |
| MGI ID | |
| Ensembl ID | ENSG00000160868 |
| Human Orthologs | CYP3A4 |
Research Application:
Description:
Intestinal expression of the CYP3A enzyme in the human body can cause significant intestinal metabolism of the compound, resulting in impaired drug absorption. This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the Villin1 promoter together with the IRES-tdTomato reporter gene into mosue Rosa26 site, which can be crossed with the Cyp3a13 gene knockout and other Cyp3a family genes knockout mice to obtain intestinal-expressed CYP3A4 humanized mouse model in order to determine the contribution of intestinal metabolism to the absorption and distribution of test article.