Immunotherapy
R26-(Liver-CYP3A4)
R26-(Liver-CYP3A4)
Nomenclature
FVB-Gt(ROSA)26Sorem1(Liver-CYP3A4)Asc
Cat. NO.ASKI-18032
Strain State
Gene Summary:
| Synonyms | HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1 |
| NCBI ID | 1576 |
| MGI ID | |
| Ensembl ID | ENSG00000160868 |
| Human Orthologs | CYP3A4 |
Research Application:
Description:
This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article.