Cre-mediated recombination system
Alb-CreERT2
Alb-CreERT2
Nomenclature
B6.129S-Albtm1.1(CreERT2)/Asc
Cat. NO.ASKI-00002
Strain State
Gene Summary:
| Synonyms | Alb1, Alb-1, BCL002 |
| NCBI ID | 11657 |
| MGI ID | 87991 |
| Ensembl ID | ENSMUSG00000029368 |
| Human Orthologs | ALB |
Research Application:
Description:
Exons 1-7 were replaced by CreERT2 and a loxp neo cassette. The KI mice have a tamoxifen-inducible cre-mediated recombination system.
Validation Data
Figure 1. X-gal staining of liver slides of Alb-CreERT2 and LacZ positive mouse before and after tamoxifen injection.
Figure 2: Immunofluorescence analysis of liver using anti-Alb (Green) and anti-LacZ (Red) antibodies showed that Cre is expressed in most hepatocytes.
Figure 3: Blood biochemical assay of Alb-CreERT2 male and female mice. Alb-CreERT2 mice do not display any liver functional abnormalities.
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