The endogenous mouse Il1b gene was replaced by human IL1B gene.
Validation Data
Figure 1. Detection of IL-1B expression in spleen and lung by RT-PCR. Wild type: only one band at 209 bp with primers F1/R1 (mIl-1b); Heterozygous: one band at 209 bp with primers F1/R1 (mIl-1b) and one band at 291 bp with primers F2/R2 (hIL-1B); Abbr.. M