The endogenous mice Cd2 gene was replaced by human CD2 gene.
Validation Data

Figure1. Detection of CD2 expression in thymus and spleen by RT-PCR. Wild type: only one band at 432 bp with primers F1/R1 (mCd2); Heterozygous: one band at 432 bp with primers F1/R1 (mCd2) and one band at 228 bp with primers F2/R2 (hCD2); Abbr. M