Humanized
PD-1 & PD-L1
PD-1 & PD-L1
Nomenclature
ENSMUSG00000026285, ENSMUSG00000016496
Cat. NO.ASHU-00100
Strain State
Gene Summary:
| Synonyms | C57BL/6 - Pdcd1<sup>em1(hPDCD1) </sup> Cd274<sup>em1(hPD - L1)/Asc</sup> |
| NCBI ID | C57BL/6 |
| MGI ID | 18566, 60533 |
| Ensembl ID | 104879, 1926446 |
| Human Orthologs | Humanized |
Research Application:
Description:
Strategy for Generating Humanized PD-1 Mouse Model
Strategy for Generating Humanized PD-L1 Mouse Model
Expression of hPD-1 and hPD-L1 was Confirmed by Flow Cytometry in Double-humanized PD-1 and PD-L1 Mice
Figure 1. The expression of human PD-1 and PD-L1 in double humanized PD-1&PD-L1 mice was confirmed by FACS.
In Vivo Validation of the Double Humanized PD-1 and PD-L1 Mice Demonstrate Their Suitability for Antibody Efficacy Studies
Figure 2. In vivo validation of double humanized PD-1&PD-L1 mice. The double humanized mice were inoculated with MC38 cells