Humanized
KDR
KDR
Nomenclature
ENSMUSG00000062960
Cat. NO.ASHU-00098
Strain State
Gene Summary:
| Synonyms | C57BL/6J - Kdr<sup>tm2(hKDR)/Asc</sup> |
| NCBI ID | C57BL/6J |
| MGI ID | 16542 |
| Ensembl ID | 96683 |
| Human Orthologs |
Research Application:
Description:
The endogenous mouse Kdr gene was replaced by human KDR gene .
Validation Data
Figure 1. Expression of mouse KDR and human KDR in C57BL/6 wild type mice and KDR-HU homozygous mice.
Figure 2. In vivo validation of anti-tumor efficacy in a B16F1 tumor-bearing model of humanized KDR mice. The results showed: The drugs targeting human KDR were associated with a very significant anti-tumor