Generation Strategy
Strategy for Generating Humanized PD-1 (ASHU-00015) Mouse Model
Strategy for Generating Humanized CTLA4 (ASHU-00014) Mouse Model
The Expression of hPD-1 in Stimulated T Cells from Double Humanized PD-1 & CTLA4 Mice
Figure 1. The expression of human CTLA-4 in double humanized PD-1 & CTLA-4 mice was confirmed by FACS.
Figure 2. In vivo validation of double humanized PD-1 & CTLA-4 mice. The Double humanized mice were inoculated with MC38 cells